Fresh analysis reveals that individuals who come off new GLP-1 drugs like Mounjaro or Wegovy may regain lost weight much more quickly than those who halt conventional diet and exercise plans.
Findings released in a leading health publication points out that while obese people often shed a large proportion of their body weight while using the jabs, the mass returns at an estimated rate of 0.8 kg per month once they quit.
"People using these drugs must be cognizant of the danger of rapid rebound weight gain when the treatment is stopped," stated researcher Dr. Susan Jebb.
That rate of regain implies a reversion to original weight within about one and a half years.
Analyzing Approaches
The analysis, which reviewed dozens of studies involving thousands of patients, contrasted the effects of the injectable medications with older methods.
The team note that people who shed pounds through dieting generally experience a more gradual creep back—perhaps 100 grams monthly—post-intervention.
Explaining the Quick Regain
Experts propose the way of the injections accounts for the amplified weight return.
These medications mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Long-term administration of the hormone levels far above than normal might result in the body to generate a reduced amount of its own natural GLP-1, and may also diminish sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this hormone supplement means appetite is no longer kept in check, making excessive eating much more probable."
An Ongoing Disease?
The NHS advise the injections for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals say that, considering the significant potential of weight regain, the treatment should be considered life-long.
This perspective is supported by drug manufacturers, who say that the findings "emphasize the long-term nature of excess weight," similar to managing conditions like high blood pressure.
User Experiences
People who have discontinued the jabs describe a intense resurgence of cravings.
"It felt as if a switch flipping and I was suddenly starving," recalled a patient.
This challenge is exacerbated if individuals have not established sustainable dietary or behavioural changes during treatment.
Growing Use
Recent estimates show that millions of people in the UK have used these injections in the past year, with interest being substantial.
- Use is greater among women than men.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion access the drugs through private healthcare rather than public health services.
In conclusion, researchers stress that while these medications are powerful tools for shedding pounds, they are not a standalone solution and maintained weight loss relies on integrated lifestyle changes.
